Reinventing medicines

Our investigational medicines can offer simple new ways for patients and caregivers to use proven and trusted molecules. Our late-stage pipeline includes several investigational treatments for CNS conditions, where patients face great difficulty in using medication because of the impact of their disease.¹ Looking ahead, we see even greater potential for PharmFilm® technology to improve patient treatment and are working to deliver complex molecules, proteins, and peptides on oral film with newer prodrugs and technologies.

Product Pipeline

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Program

Molecule

Targeted Indication

Formulation Pre-Clinical/Proof of Concept Phase 1 Phase 2 Phase 3 Filed Marketed

CNS Programs

LIBERVANT^TM*
(Seeking Partner Outside US)

diazepam^†

Breakthrough Seizures / Cluster Seizures

Filed

FDA accepted NDA February 2020

In development as an oral rescue therapy for breakthrough seizures / cluster seizures

Complex Molecule Programs

AQST-108

epinephrine^†

Anaphylaxis, severe allergy

Phase 1

In development as a treatment for anaphylaxis, severe allergy

AQST-109

epinephrine^†

Anaphylaxis, severe allergy

Phase 1

In development as a pro drug treatment for anaphylaxis, severe allergy

AQST-305

octreotide^†

Acromegaly / Carcinoid syndrome

Pre-Clinical/Proof of Concept

Pre-Clinical/Proof of Concept, proof of concept clinical studies in progress

In development as a treatment for patients with acromegaly and neuroendocrine tumors

Licensed programs

SUBOXONE®
(Partner: Indivior)

buprenorphine / naloxone

Marketed since 2010

For more information, visit www.suboxone.com or download the Prescribing Information

ZUPLENZ®
(Partner: Hypera Brazil)

ondansetron

Marketed since 2010

For more information, visit www.zuplenz.com or download the Prescribing Information

KYNMOBI^TM
(Partner: Sunovion)

apomorphine^†

Approved since 2020

For more information, visit www.kynmobi.com or download the Prescribing Information

EXSERVAN^TM
(EU Partner: Zambon;
US Partner: Mitsubishi Tanabe)

riluzole

Licensed since 2019

AQST-119
(Partner: IntelGenx)

tadalafil^†

Filed

*Aquestive has received conditional acceptance of the use of this trade name, which is subject to final FDA review and acceptance

^†Subject to review, evaluation, and approval of the FDA

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References

1. Holsti M, Dudley N, Schunk J, et al. Intranasal midazolam vs rectal diazepam for the home treatment of acute seizures in pediatric patients with epilepsy. Arch Pediatr Adolesc Med. 2010;164(8):747–753.

2. Fischer D, Vander Leek TK, Ellis AK, Kim H. Anaphylaxis. Allergy Asthma Clin Immunol. 2018;14(Suppl 2):54

3. Wood RA, Camargo CA Jr, Lieberman P, et al. Anaphylaxis in America: the prevalence and characteristics of anaphylaxis in the United States. J Allergy Clin Immunol. 2014 Feb;133(2):461-467.

4. Ma L, Danoff TM, Borish L. Case fatality and population mortality associated with anaphylaxis in the United States. J Allergy Clin Immunol. 2014;133(4):1075-1083.

SYMPAZAN® is a registered trademark of Aquestive Therapeutics, Inc.
SUBOXONE® is a registered trademark of Indivior UK Ltd.
ZUPLENZ® is a registered trademark of Midatech Pharma US Inc.
DIASTAT® is a registered trademark of Bausch Health Companies, Inc.
KYNMOBI^TM is a trademark of Sunovion Pharmaceuticals, Inc.

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Whether we are partnering to out license our PharmFilm® technology or in-licensing adjacent assets, Aquestive works hand-in-hand with our partners to address their toughest clinical and business challenges. To learn more, please complete the following form:

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To subscribe to receive information updates about products and services from Aquestive Therapeutics, or to receive information about Aquestive-sponsored clinical trials, please check the box below. Please also review our privacy policy, which describes how we use and process your data. You may also contact us at any time by emailing busdev@aquestive.com.
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Pipeline

An expanding portfolio

Reinventing medicines

Product Pipeline

In development as an oral rescue therapy for breakthrough seizures / cluster seizures

In development as a treatment for anaphylaxis, severe allergy

In development as a pro drug treatment for anaphylaxis, severe allergy

In development as a treatment for patients with acromegaly and neuroendocrine tumors

Essential information for the investment community

Aquestive sponsored clinical trials

Clinical trial news and other updates

References

Please complete this form:

Please complete the form below and click SEND to receive a copy of “Overcoming Solubility and Permeability Challenges,” a case study detailing the achievements made by Aquestive’s formulation team to create the diazepam buccal film.

Please complete the form to receive a demonstration kit for our PharmFilm® technology.

Please complete this form:

Whether we are partnering to out license our PharmFilm® technology or in-licensing adjacent assets, Aquestive works hand-in-hand with our partners to address their toughest clinical and business challenges. To learn more, please complete the following form:

Please complete the form below and click submit to receive a copy of “The Art of LGS Book.”