Innovative
Drug Delivery

Optimizing delivery based on drug properties and clinical need

Changing the way drugs are developed and delivered can have a positive impact for patients and caregivers. Aquestive Therapeutics is the primary innovator and worldwide leader in developing medicines on oral films to maximize their usability.

Independently and with partners, our quest is to leverage our highly customizable PharmFilm® technology to solve therapeutic problems and meaningfully improve the lives of people who face barriers to using important medications.

A PharmFilm® medication arranged vertically

PharmFilm® is a unique and versatile technology for high-performance drug delivery. Aquestive scientists combine the customizable features of PharmFilm® with patented formulation and engineering processes to optimize the delivery of active pharmaceutical ingredients (APIs).

PharmFilm® technology provides the development platform for our expanding pipeline of proprietary and partner-developed products.

A PharmFilm® medication in the opening frame of the video,

PharmFilm® Drug Differentiation by Design

Opening frame of video showing the phrase

Aquestive’s Commitment to Improving Lives Through PharmFilm® Technology

Two strips of PharmFilm® aligned vertically

Take your API further

Optimize the administration route

Sublingual, lingual, or buccal drug delivery gives patients with complex dosing challenges a simple, non-invasive, and more convenient way to dose. No mixing, swallowing, or chewing.1 The degree of mucosal permeability and desired product profile are used to determine the targeted route of delivery. In this way, Aquestive’s Development Services team can tailor treatments to optimize a drug’s pharmacokinetic profile and meet the requirements of specific patient populations.

A PharmFilm® medication being applied to the inside of a cheek (buccal delivery)

Buccal

Controlled release and engineered retention time in a controlled microenvironment

A PharmFilm® medication being applied under the tongue (sublingual delivery)

Sublingual

Rapid onset of action with direct entry into systemic circulation

A PharmFilm® medication being applied directly onto the tongue (lingual delivery)

Lingual

Rapid disintegration and controlled release with bioequivalancy to tablets and capsules

Redesigning medicines for optimal product usability

Every medicine is different, so Aquestive follows a drug-by-drug approach for harnessing film technology to achieve target product profiles and clinical improvement goals. Customized to the chemical structure of the API, the Formulation Engineering team leverages proprietary PharmFilm® technologies, pH modifiers, and permeation enhancers to achieve target absorption.

Formulating products for high-performance drug delivery

Customized film designs maximize transcellular and intercellular transport across the mucosa

Expertise in applying pH modifiers and permeation enhancers for targeted absorption

Custom Film Formulation and Engineering

Expert scientists tailor blends of polymers, prodrugs, and excipients to optimize drug release and bioavailability

The compositional profile of the custom formulation is used to establish the optimal rate of dissolution

Unique polymer blends hold the API and excipients in place, preserving the original structure

Patented techniques are applied to ensure uniform distribution

Customizable Features

Adaptable polymer matrix

Array of FDA-approved permeation enhancers

Variety of flavors

Range of drug loads

Potential PharmFilm® advantages

Illustration of a horizontal strip of PharmFilm® with 3 vertical arrows pointing in different directions

3 possible routes of administration (based on API)

Illustration of a horizontal strip of PharmFilm® with 3 drops of liquid approaching the PharmFilm®

Optimized absorption and onset of action

Illustration of a horizontal strip of PharmFilm® with a single arrow pointing down toward the PharmFilm®

Reduced drug exposure

Silhouette of a human head with the mouth open. A single strip of PharmFilm® is located near the mouth.

Easy, convenient dosing

Illustration of the 3 possible routes of administration for PharmFilm®: sublingual, lingual, and buccal.

VS

Illustration of conventional routes of administration, such as syringes and mixing crushed medicine with food
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Commercial partners

Trust in a global leader with a proven history of bringing novel drugs successfully to market

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Physicians

A proven option for delivering important medicines in accurate doses to patients

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Patients

Access to important medications that are simple to dose, where you need it, when you need it™

Learn more about PharmFilm®

Contact the Aquestive business development team at busdev@aquestive.com

Reference

1. Slavkova M, Breitkreutz J. Orodispersible drug formulations for children and elderly. Eur J Pharm Sci. 2015;(75):2-9.

Please complete this form:

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Please complete the form below and click SEND to receive a copy of “Overcoming Solubility and Permeability Challenges,” a case study detailing the achievements made by Aquestive’s formulation team to create the diazepam buccal film.

  • To subscribe to receive marketing updates about diazepam buccal film and other products and services from Aquestive, please complete the form below. Please also review our privacy policy, which describes how we use and process your data. You may also contact us at any time by emailing busdev@aquestive.com.

Please complete the form to receive a demonstration kit for our PharmFilm® technology.

  • To subscribe to receive marketing updates about our PharmFilm® technology and other products and services from Aquestive, please complete the form below. Please also review our privacy policy, which describes how we use and process your data. You may also contact us at any time by emailing busdev@aquestive.com.

Please complete this form:

  • To subscribe to receive marketing updates about products and services from Aquestive Therapeutics, or to receive information about Aquestive-sponsored clinical trials, please check the box below. Please also review our privacy policy, which describes how we use and process your data. If for any reason you no longer wish to receive information on Aquestive-sponsored clinical trials, you can contact us at any time by emailing clinicaltrials@aquestive.com.

Whether we are partnering to out license our PharmFilm® technology or in-licensing adjacent assets, Aquestive works hand-in-hand with our partners to address their toughest clinical and business challenges. To learn more, please complete the following form:

  • To subscribe to receive information updates about products and services from Aquestive Therapeutics, or to receive information about Aquestive-sponsored clinical trials, please check the box below. Please also review our privacy policy, which describes how we use and process your data. You may also contact us at any time by emailing busdev@aquestive.com.